Polymorphisms in ADAM33 are associated with allergic rhinitis due to Japanese cedar pollen
نویسندگان
چکیده
منابع مشابه
Development of experimental allergic rhinitis model using Japanese cedar pollen.
および鼻閉を主症状とする典型的な I型アレルギー疾 患である.くしゃみおよび鼻汁分泌の亢進は,抗ヒス タミン薬により抑制される.一方,患者にとって最も 苦痛を強いられる鼻閉にはグルココルチコイドが繁用 されるが,周知のごとくグルココルチコイドは優れた 効果を発揮するが副作用も強く,これに代わる鼻閉の 治療薬が望まれている.実験動物を用いたヒトの病態 を反映した良好なモデルは,新規治療薬の開発に極め て重要な位置にあることは論をまたない.そこで,我々 はモルモットを用いてスギ花粉抽出エキスで経鼻的に 感作し,以後スギ花粉の反復吸入を行うことにより, ヒトの病態に類似した症状を呈するアレルギー性鼻炎 モデルの開発を企図した.本法により,抗原惹起後に 明らかなくしゃみおよび二相性の鼻閉が認められ,く しゃみの発現は周知のごとく抗ヒスタミン薬で強力に 抑制された.一方,遅発性の鼻閉は,システ...
متن کاملOmalizumab is effective and safe in the treatment of Japanese cedar pollen-induced seasonal allergic rhinitis.
BACKGROUND Seasonal allergic rhinitis (SAR) induced by Japanese cedar pollen is a substantial problem in Japan. Omalizumab, a novel humanized monoclonal anti-immunoglobulin E (IgE) antibody, has already been proven to reduce symptoms associated with SAR. We investigated the safety and efficacy of omalizumab in the treatment of patients with Japanese cedar pollen-induced SAR compared to placebo....
متن کاملA new model of experimental allergic rhinitis using Japanese cedar pollen in guinea pigs.
In the majority of the models of experimental allergic rhinitis, antigen challenge has been performed by single topical instillation or perfusion with the solution. The present study was performed to establish a good model using Japanese cedar pollen, which is able to repeatedly induce allergy restricted to the upper airway. Guinea pigs sensitized with the pollen extracts were subjected to quan...
متن کاملRole of Prostaglandin D2 and DP1 Receptor on Japanese Cedar Pollen-Induced Allergic Rhinitis in Mice.
Although we previously demonstrated the contribution of the DP1receptor in nasal obstruction using animals sensitized with ovalbumin in the presence of adjuvant, the contribution of the DP1receptor in sneezing is unclear. Here, we developed a mouse model of Japanese cedar (JC:Cryptomeria japonica) pollinosis to evaluate the symptoms of sneezing. To achieve this, we used JC pollen crude extract ...
متن کاملGATA3 Gene Polymorphisms Associated with Allergic Rhinitis in an Iranian Population
Background: The development of allergic rhinitis (AR) is caused by the interaction between genetic predisposition and environmental factors. In this study, the association between GATA3 single nucleotide polymorphisms and AR in an Iranian population was identified. Methods: This case-control study was performed on 86 patients with AR and 86 healthy subjects. This study aimed to e...
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ژورنال
عنوان ژورنال: Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy
سال: 2004
ISSN: 0954-7894,1365-2222
DOI: 10.1111/j.1365-2222.2004.02008.x